You should wear long sleeve garments and disposable gloves to minimize skin contact. Safety goggles will protect your eyes in the event that inadvertent splashing of a material occurs.
Skin Contact? Lightly wipe affected area immediately with solvent and then wash thoroughly with soap and water.
Eye Contact? If contaminated, flush eyes with water for 15 minutes and seek immediate medical attention.
Avoid breathing in plaster dust, mist from aerosol sprayers or fumes of any kind, etc. When using any material associated with mold making and casting, you must have "room size" ventilation (400 ft² / 38 m²) or greater.
If using these materials on a regular basis, you should install an external ventilation system in your workshop and use all materials in proximity to the working vent. Wearing a NIOSH-approved respirator will further minimize risk of inhalation.
Spraying Material? If you are spraying rubber, plastics or foams, try to do your spraying outdoors in an open space. Regardless of spraying outdoors or inside, anyone in the spray area must wear a NIOSH-approved respirator and disposable gloves at the very least.
There is a class of polyurethane chemistry known as "aliphatic isocyantes" that require extra handling precautions. These are for "industrial use" only and should not be used by students, hobbyists, etc.
If using one of these products, you must wear a NIOSH-approved respirator, long sleeve garments and disposable gloves to avoid skin contact.
If you are having an allergic reaction while using polyurethanes, stop using them and seek immediate medical attention.
Symptoms Include: if you are having trouble breathing, experiencing throat discomfort, itching eyes, and/or a skin rash, you may be having a reaction to these materials.
Cease and Desist – Permanently! If you experience these symptoms following any exposure to a urethane product, chances are you have become sensitized and you will experience a reaction every time. At this point, you should avoid using urethanes.